In 1920, area Presbyterians built a manse under the supervision of the Rev. Horace N. Cunningham; services were held in the building. In January 1921, seven charter members organized First Presbyterian Church. They completed a church building in 1923; it was replaced in 1951 by a larger church, designed by noted area architect and church member, William C. Baxter. Members have long worked with the needy, including outreach activities for low-income residents on the U. S. - Mexico border. The congregation also supported organization of the Spanish-speaking San Pablo Presbyterian Church. Today, First Presbyterian Church of Weslaco continues to serve as a spiritual leader in the community. (2010)