In 1857, prior to the incorporation of the town of Mesquite, a group of area residents began gathering occasionally for Methodist worship services led by circuit riding preacher W. K. Masten. Services were held in a nearby building known variously as the Frost Schoolhouse or the Bennett Schoolhouse. By 1863, the group had organized formally as the First Methodist Episcopal Church, South. Services continued in the schoolhouse until 1880, when charter members John L. and Lucy Futrell deeded this land to the congregation for the construction of a church building. Soon a small wood-frame structure was erected. Later damaged by a storm, it was rebuilt in 1900. In 1887 when the town of Mesquite was incorporated, charter member J. E. Russell became the town's first mayor, and the downtown area began to develop near the church site. As the population of Mesquite increased, so did the congregation, and several progressively larger sanctuaries were built after 1916 to accommodate its growth. Because of denominational mergers, the congregation changed its name to the First Methodist Church of Mesquite in 1939, and to the First United Methodist Church of Mesquite in 1968.