Established by Franciscan missionaries in 1749 with the hope of civilizing and christianizing the Coco, Mayeye, Orcoquiza, Karankawa, and other tribes of Indians. The martyrdom of Padre Jose Ganzabal and the circumstances connected therewith caused the departure of the Indians and the friars and the removal of this mission to the San Marcos River in 1755. Reestablished in 1762 on the Nueces River for the conversion of the Lipan Apaches with the new name of Mission San Lorenzo de la Santa Cruz.